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冯超教授课题组在Angewandte Chemie International Edition发表研究论文
阅读次数:402 添加时间:2017-12-13 发布: 管理员

Fluorine Effects on Group Migration via a Rhodium(V) Nitrenoid

Intermediate


Cheng-Qiang Wang, Yu Zhang, and Chao Feng*

Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 211816, China

 

Abstract: An unprecedented rhodium(III)-catalyzed hydroarylation of a,a-difluoromethylene alkynes with N-pivaloxyl aroylamides through sequential C@H activation and aryl migration is detailed herein. A large array of a,a-difluoromethylene alkynes and N-pivaloxyl aryl amides were amenable to this transformation, thus providing a novel synthetic protocol for the construction of difluorinated 2-alkenyl aniline derivatives in high yields and with excellent regioselectivity. Notably, unique fluorine effects were found to underlie the thus unconventional reaction manifold.



Angew. Chem. Int. Ed. 2017, 56, 14918–14922 (2017年影响因子: 11.994).

论文链接:http://onlinelibrary.wiley.com/doi/10.1002/anie.201708505/abstract



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