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胡绪红教授和罗德平教授课题组在Chemical Communications发表研究论文
阅读次数:585 添加时间:2017/11/27 发布: 管理员

Iron-catalyzed Peroxidation-Carbamoylation of Alkenes with Hydroperoxides and Formamides via Formyl C(sp2)-H Functionalization

Jun-Kee Cheng,b Liang Shen,b Liu-Hai Wu,b Xu-Hong Hu*a and Teck-Peng Loh*ab

a Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 211816, China.

b Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.


Abstract: A reaction protocol in which FeCl3 and tert-butyl hydroperoxide facilitated selective radical coupling reaction of aryl alkenes or 1,3-enynes with tert-butyl hydroperoxide and formamides to prepare an array of β-peroxy amides has been achieved. The β-peroxy amide could serve as synthetic precursor which was facilely converted to β-hydroxy amide, β-keto amide and β–lactam following subsequent chemical transformation.

Chemical Communications, 2017, DOI: 10.1039/c7cc08074c (2017年影响因子6.319)


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