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沈志良教授和罗德平教授课题组在ACS Catalysis发表论文
阅读次数:332 添加时间:2017-11-23 发布: 管理员

Recent Advances in Radical-Initiated C(sp3)-H Bond Oxidative Functionalization of Alkyl Nitriles

Xue-Qiang Chu,a Danhua Ge,a Zhi-Liang Shen,*a and Teck-Peng Loh*ab

a Institute of Advanced Synthesis, College of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 210009, China

b Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore

Abstract: Chemoselective functionalization of intrinsically less reactive C(sp3)–H bonds of alkyl nitriles are of particular interest to the chemical community in view that these strategies provide opportunities for the introduction of important cyanoalkyl groups onto target frameworks in a step-economic fashion. In recent years, the introduction of nitrile-containing alkyl radicals in tandem radical additions and oxidative couplings inarguably brings chemists a new radical reaction platform for the diverse synthesis of natural products and pharmaceuticals. Compared with the wide applications of various C-centred radicals adjacent to a heteroatom, however, the nitrile-containing alkyl radicals remain largely unexplored. New methods for C(sp3)?H bond oxidative functionalization of alkyl nitriles and new mechanistic manifolds would result in the development of a broad range of novel reactions. Therefore, this review will give an overview of various types of radical cyanoalkylation by using the key alkyl nitrile reactants, which is beyond traditional coupling chemistry.

ACS Catalysis, 2017, Just Accepted Manuscript (DOI: 10.1021/acscatal.7b03334) (2017年影响因子: 10.6; 论文第一作者为助理教授褚雪强博士).



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