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冯超教授和罗德平教授课题组在Organic Letters发表研究论文
阅读次数:832 添加时间:2017/11/8 发布: 管理员

Photoredox Catalysis Induced Bisindolylation of Ethers/Alcohols via

Sequential C—H and CO Bond Cleavage

Lu Ye,a Sai-Hu Cai,a,b Ding-Xing Wang, a Yi-Qiu Wang, a Lin-Jie Lai, a Chao Feng,*,a

and Teck-Peng Loh*,b,c

a Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 211816, China

b Department of Chemistry, University of Science and Technology of China, Hefei 230026, P. R. China

c Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore


Abstract: A visible-light-engaged 2-fold site-selective alkylation of indole derivatives with aliphatic ethers or alcohols has been accomplished for easy access to symmetric 3,3’-bisindolylmethane derivatives. The experimental data suggest a sequential photoredox catalysis induced radical addition and proton-mediated Friedel?Crafts alkylation mechanism.

Organic Letters 2017, DOI: 10.1021/acs.orglett.7b03073 (2017年影响因子: 6.579).


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