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冯超教授和罗德平教授课题组在Chemical Communications发表研究论文
阅读次数:865 添加时间:2017/10/12 发布: 管理员

Nonconventional difluoroalkylation of C(sp2)–H bonds through hydroarylation

Chuan Zhu,#a Shengjin Song,#ab Lu Zhou,a Ding-Xing Wang,a Chao Feng*a and

Teck-Peng Loh*bc

a Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 211800, P. R. China

b Department of Chemistry, University of Science and Technology of China, Hefei 230026, China

c Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore


Abstract: An unprecedented Rh-catalyzed C2-difluoroalkylation of indole derivatives with 2,2-difluorovinyl arenesulfonates has been reported. This reaction provides a rare instance of catalytic difluoroalkylation through hydroarylation of gem-difluoroalkenes. The sulfonate group works as a chelating ligand, thus stabilizing the rhodacycle intermediate, leading to the uncommon transformation.

Chemical Communications 2017, 53, 9842-9845 (2017年影响因子: 6.3).


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